Synthesis and Antimicrobial Activity of Some New Coumarin Incorporated Pyridine-3-carbonitrile Derivatives

Drug resistance causes serious difficulties in the routine therapy for curing common microbial infections. Thus it is very essential to develop new antimicrobial agents which can offer alternative treatments. The development of potent and effective utmost importance overcome emerging multidrug strains bacteria fungi. technique involves Knoevenagel reaction between substituted salicylaldehyde ethyl acetoacetate presence piperidine as catalyst give 3-acetyl coumarin. intermediate coumarinyl chalcones was synthesized by condensing with various benzaldehyde ethanolic KOH. final pyridine-3-carbonitrile derivative prepared upon refluxing malononitrile ammonium acetate. All newly compounds were assigned on basis IR, 1H NMR mass spectral data. finalsynthesized screened their antibacterial activity tube dilution method. Most showed promising MIC method compared standard Cephalosporin.